Role of high molecular weight hyaluronic acid in postmenopausal vaginal discomfort

Role of high molecular weight hyaluronic acid in postmenopausal vaginal discomfort. a double-blind placebo-controlled study

Article specifications

This clinical trial was published in 2012 in Journal of Minerva ginecologica (IF2015: 1.07) by Italian gynecologists. In this study 36 post-menopausal women, equally distributed in placebo and active group with high molecular weight hyaluronic acid. After the written informed consent, the participants were instructed to apply the gel (drug or placebo) daily. Three days after the end of the treatment the patients received a final examination to evaluate the progress of symptoms, the presence of any adverse events and their correlation with the treatment.

Results

The results of the study showed that High molecular weight hyaluronic acid could be effective in subjective and objective improvement of postmenopausal vaginal atrophy providing a good compliance. No adverse events occurred during the entire period of the study.