Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial

Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial. A Randomized, Double-blind Comparison study

Article specifications

This clinical trial was published in 2012 in African Journal of Pharmacy and Pharmacology (IF 2014:0.293) by Iranian midwifes.  In this study 44 women(age between 45 and 65 years, with physiological menopause for at least 1 year or have hormone test with Follicle stimulating hormone (FSH) level more than 40 unit, presence of normal pap smears in the last 3 months, presenting symptom of vaginal atrophy, vaginal pH more than 5, superficial vaginal cells with 5% or less and sexual activity with vaginal atrophy) were randomized in two groups to treated with vaginal suppositories containing 1 mg vitamin E daily for 14 days, and subsequently, one suppository three days a week and group II (n = 22) treated with vaginal suppositories in the form of HA, 5 mg for the same period. The symptoms of vaginal atrophy were evaluated by a self-assessed 4-point scale. Vaginal pH and maturation value were measured and compared in both groups.

Results

The results of the study showed significant improvement in vaginal symptoms, vaginal pH and vaginal maturation index in both vitamin E and hyaluronic acid treatment, but this improvement was more significant in patients who take vaginal suppositories containing hyaluronic acid.