The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial
The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial
Article specifications
This randomized clinical trial was published in 2011 in Archives of Gynecology and Obstetrics (IF 2015:1.24) by Turkish gynecologists. In this study the effectiveness of the vaginal tablets of hyaluronic acid and estradiol for the treatment of atrophic vaginitis were compared. 42 postmenopausal women with symptoms of atrophic vaginitis were randomized to take vaginal tablets of 25 macro gram estradiol (n=21) (group I) or 5 mg hyaluronic acid sodium salt (n=21) (group II) for 8 weeks. All participants had serum E2 concentrations of 20 pg/mL or less, with 5% or less superficial vaginal cells. Participants were also required to be at least 12 months postmenopausal, with an endometrial thickness of 5 mm or less as determined by transvaginal ultrasonography. The symptoms of atrophic vaginitis were evaluated by a self-assessed 4-point scale of composite score and the degree of epithelial atrophy was determined as, none, mild, moderate and severe. Vaginal pH and maturation index were measured and compared in both the groups.
Results
The results of the study showed that hyaluronic acid tablet is an effective and safe alternative for estradiol I treatment of vaginal atrophy. We have found significant improvement in vaginal symptoms, epithelial atrophy, vaginal pH and vaginal maturation index.
