Comparing the Effect of a hyaluronic acid and carboxymethylcellulose with steroid-antibiotics on ocular comfort after cataract surgery

Effect of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgery: A Multicenter, Randomized Clinical Study

Article specifications

This article was published in 2015, In journal of cataract & refractive surgery (IF2015: 2.72) by Italian surgeons. This study enrolled 282 patients scheduled for unilateral cataract surgery. After surgery, patients received artificial tears and a topical steroid–antibiotic (study group) or topical steroid–antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were tear breakup time (TBUT), ocular surface disease index (OSDI), frequency of dry-eye symptoms evaluated using a visual analog scale (VAS), and corneal fluorescein staining. A total of 298 patients (298 eyes) were randomized to the study group and the control group in a 1:1 ratio. Patients were adults 18 years or older.

Results

In the present study, sodium hyaluronate 0.1% and carboxymethylcellulose 0.5% ophthalmic solution with steroid-antibiotic administered after cataract surgery was more effective than a topical steroid–antibiotic alone in reducing dry eye disease symptoms that developed gradually over the postoperative period.