Investigate the effect of sodium hyaluronate on human corneal epithelial cell migration, proliferation, and CD44 receptor expression

Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro

Article specifications

This clinical trial was published in 2004 in Journal of Br J Ophthalmol. (IF 2004: 1.60) by Britannia specialists. The purpose of this study was to investigate the effect of sodium hyaluronate on human corneal epithelial cell migration, proliferation, and CD44 receptor expression.

 

Results

Sodium hyaluronate promotes migration but not proliferation or CD44 expression on human corneal epithelial cells in vitro. The beneficial effect of sodium hyaluronate in corneal wound healing is likely to be related to rapid migration of cells leading to rapid wound closure. This may be facilitated by the adhesion between CD44 on the cells and hyaluronic acid, which coats the surface of the denuded cornea.