Carbomer and Sodium Hyaluronate Eyedrops comparison for Moderate Dry Eye Treatment

Carbomer and Sodium Hyaluronate Eyedrops for Moderate Dry Eye Treatment. A randomized, double-masked study.

Article specifications

This clinical trial was published in 2008 in journal of optometry and vision science (IF 2016:1.409) by American ophthalmologists.

In this study the effectiveness of 2 ocular lubricants containing either 0.3% Carbomer 934 or 0.18% sodium hyaluronate (SH) in treating moderate dry eye was compared. 65 patients with medium dry eye syndrome were divided in 2 groups and treated either with carbomer or hyaluronic cid for a month. Principle outcome measures were the severity of symptoms of ocular irritation, tear break-up time without (NIBUT) and with (TBUT) fluorescein, and corneal and conjunctival staining with fluorescein and lissamine green, respectively. At the end of the experiment, subjects were also asked, on average, how many times a day they used the treatment and the duration of any post instillation blur.

Results

The study showed that both of the lubricants reduced the severity of symptoms and extent of ocular surface staining in subjects with moderate dry eye after use for a month, but neither had a lasting effect on tear film stability. Although SH-containing treatment has marginal benefits in terms of therapeutic efficacy and has less propensity to cause visual disturbance on instillation.