Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C

Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C.

Article specifications

This clinical trial was published in 2008 in journal of Eye (IF 2016:2.275) by Japanese ophthalmologists. The purpose of this study was the efficacy of sodium hyaluronate eye drops for prevention of late-onset bleb leakage after trabeculectomy with mitomycin C (MMC). S68 eyes of 68 patients who had trabeculectomy with MMC divided in 2 groups: 22 were treated postoperatively with sodium hyaluronate eye drops (sodium hyaluronate group) and 46 eyes were not treated postoperatively (control group). The blebs were classified according to the avascular area, epithelial defect and degree of bleb wall leakage. Both groups were assigned classes (0, avascular or partial avascular bleb; 1, avascular or partial avascular bleb with an epithelial defect; 2, avascular or partial avascular bleb with oozing; 3, avascular or partial avascular bleb with a point of leakage).

Results

The results of the article showed that use of sodium hyaluronate eye drops in class 0 or class 1 cases may prevent the development of late-onset bleb leaks. However, if flattening or encapsulation is observed, sodium hyaluronate eye drops should be stopped immediately in order to maintain bleb function.