Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis

Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis.

Article specifications

This Randomized, Masked-observer, Parallel-groupclinical trial was published in 2005 in Graefe's Archive for Clinical and Experimental Ophthalmology (IF2016/2017: 2.349) by French ophthalmologists. In this study the efficacy of a 0.18% SH or 1% CMC solution in dry eye syndrome with superficial keratitis.

A total of 22 patients with moderate dry eye and superficial keratitis were enrolled in this study. Patients were randomly assigned to a 0.18% SH or 1% CMC solution for a 2-month period, Three follow-up visits were scheduled, namely days 7, 28 and 56. Flow cytometry analysis of CD44, HLA DR Expressions in impression cytology was investigated as a potential efficacy parameter.

Results

The results of this study showed that SH was well tolerated and tended to show a faster efficacy than did the CMC based formulation in patients with moderate dry eye and superficial keratitis.