Performance profile of sodium hyaluronate in patients with lipid tear deficiency: randomised, double-blind, controlled, exploratory study

Performance profile of sodium hyaluronate in patients with lipid tear deficiency: randomised, double-blind, controlled, exploratory study

Article specifications

This clinical trial was published in 2007 in British journal of ophthalmology (IF 2017:3.806) by ophthalmologists in Thailand. 10 patients with dry eye due to LTDwere treated as follows: one drop of hypotonic 0.18% sodium hyaluronate in one eye and one drop of isotonic 0.3% hydroxypropyl-methylcellulose (HPMC) 0.1% dextran in the other eye. Non-invasive tear film break-up time (NIBUT) evaluated by using a tear scope with grid pattern and subjective ocular symptoms of dry eye were assessed at 15, 30, 60 and 90 min after instillation.

Results

The results of this study indicated that both treatments are effected and improve tear film stability and symptoms. However, sodium hyaluronate caused a significantly greater increase in NIBUT values than HPMC/dextran in such patients.