Additive Effect of Preservative-free Sodium Hyaluronate 0.1% in Treatment of Dry Eye Syndrome with Diquafosol 3% Eye Drops

Additive Effect of Preservative-free Sodium Hyaluronate 0.1% in Treatment of Dry Eye Syndrome with Diquafosol 3% Eye Drops. A Randomize group, case-control study.

Article specifications

This clinical trial was published in 2014 in journal of cornea and external disease (IF 2017:1.833) by Korean ophthalmologists. In this study 150 patients with dry eyes divided in 3 groups: (1) 50 patients was treated with preserved sodium hyaluronate 0.1% eye drops (4 times a day). (2) 50 patients was treated with diquafosol 3% eye drops (4 times a day). (3) 50 patients was treated with diquafosol 3% and preservative-free sodium hyaluronate 0.1% eye drops (4 times a day). Ocular surface disease index (OSDI) scoring, tBUT, Schirmer I test (without anesthesia), corneal fluorescein staining, and conjunctival impression cytology10 were performed by the same investigator (E.C.K.) before treatment, and at 1, 2, and3 months after the treatment.

Results

In conclusion combination therapy with diquafosol 3% and preservative-free sodium hyaluronate 0.1% is more effective than other forms of therapies and preservative-free artificial tears do not contain a preservative that causes an inflammatory response and oxidative damage in the ocular surface and that preservative-free artificial tears can dilute the toxic effect of the preservative in diquafosol.