Treatment of carpometacarpal osteoarthritis with Hyaluronan

Injectable hyaluronan for the treatment of carpometacarpal osteoarthritis: An open label pilot trial.

Article specifications

This clinical study was published in 2009 in Journal of Curr Med Res Opin. (IF 2009:0.22) by American specialists. 32 patients with CMC OA were injected with Hylan G-F 20, once weekly for three consecutive weeks. Patients were assessed 4, 12, 20 and 26 weeks after the first injection. A last-value carried forward analysis was performed.

 

Result

Intra-articular Hylan G-F 20 injections reduced pain and improved function in patients with CMC OA at 26 weeks in this small open label study. Limitations of this study include its small, open label design. Larger randomized controlled trials are needed to confirm these results, and to determine predictors of response to treatment.