Hybrid Scaffolds of Hyaluronic Acid and Collagen Loaded with Prednisolone

Hybrid Scaffolds of Hyaluronic Acid and Collagen Loaded with Prednisolone: An Interesting System for Osteoarthritis.

Article specifications

This clinical trial was published in 2018 in Journal of Adv Pharm Bull. (IF 2015:2.01) by Iranian specialists. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair. Hybrid scaffolds containing different ratios of hyaluronic acid (HA) and collagen were prepared and loaded with prednisolone as anti-inflammatory agent. Two different dosage forms (lyophilized implantable disk and thermo-sensitive gels) were examined. A scaffold of cross-linked HA was used as control.

 

Result

It seems that this porous hybrid scaffold could be a suitable choice in cartilage regeneration as well as a controlled-release system for delivery of prednisolone in osteoarthritis.