Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis

Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: A mini-review of the literature

Article specifications

This mini-review was published in 2017 in Journal of Clin Cases Miner Bone Metab. (IF 2015:1.50) by Italian specialists. The aim of the present study was to report a mini-review of the literature on the comparison between HA and CSs injections in the non-operative management of symptomatic knee osteoarthritis, focusing on efficacy, adverse events, and safety.

 

Result

Conflicting results have been reported in clinical studies and meta-analysis on the efficacy and safety of HA. Guidelines are controversial and “uncertain” recommendations are provided in most of the cases due to inconclusive evidence in literature. However, HA does not seem to have significantly higher side effects when compared to saline or CSs injections, and provides better medium-term control of symptoms in patients with mild to moderate knee osteoarthritis.