The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee

The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review.

Article specifications

This systematic review was published in 2015 in Journal of BMC Musculoskelet Disord. (IF2015: 2.11) by American specialists. A comprehensive literature search to identify currently available primary non-clinical basic science articles focussing on the mechanism of action of IA-HA treatment. Included articles were assessed and categorized based on the mechanism of action described within them.

 

Results

The non-clinical basic science literature provides evidence for numerous mechanisms in which HA acts on joint structures and function. These actions provide support for the purported clinical benefit of IA-HA in OA of the knee. Future research should not only focus on the pain relief provided by IA-HA treatment, but the disease modification properties that this treatment modality possesses as well.