Evaluate the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint®) on pain and quality of life in subjects with osteoarthritis of the knee

Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint^®) on pain relief and quality of life in subjects with knee osteoarthritis: A pilot randomized double-blind placebo-controlled trial

Article specifications

This clinical trial was published in 2008 in Journal of Nutrition Journal (IF 2014: 2.60) by American rheumatologists. The aim of this study was to evaluate the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint^®) on pain and quality of life in subjects with osteoarthritis of the knee. Twenty subjects aged ≥40 years with knee osteoarthritis (pain for at least 15 days in the previous month, symptoms present for ≥6 months, Kellgren/Lawrence score ≥2) participated in a randomized double-blind controlled trial. Ten subjects received AP (80 mg/day) and 10 placebo for 8 weeks.

 

Results

This pilot clinical trial showed that daily supplementation with oral hyaluronic acid from a natural extract of chicken combs (Hyal-Joint^®) was useful to enhance several markers of quality of life in adults with osteoarthritis of the knee. The results warrant further study in larger sample sizes.