Efficacy and applicability of immediate post-operative intra-articular injection of hyaluronic acid (IA HA) into the knee joint with an intra-articular fracture

Prevention of post-traumatic osteoarthritis after intra-articular knee fractures using hyaluronic acid a randomized prospective pilot study.

Article specifications

This Prospective randomized case-control study was published in 2019 in Journal of Int Orthop. (IF 2017: 2.46) by Egyptian specialists. This study evaluates the clinical efficacy and applicability of immediate post-operative intra-articular injection of hyaluronic acid (IA HA) into the knee joint with an intra-articular fracture. Twenty patients with intra-articular distal femoral or intra-articular proximal tibial fractures who met our inclusion criteria received three intra-articular hyaluronic acid injections weekly starting immediately after ORIF. Another 20 patients serving as a control group received no injection after ORIF.

 

Results

These preliminary results support a direct role for hyaluronic acid in the acute phase of the inflammatory process that follows articular injury and provides initial evidence for the efficacy of IA HA.