Investigate the anti-inflammatory effects and properties of hybrid cooperative complexes based on high and low molecular weight hyaluronan (HCC) compared to H-HA on human primary cells derived by pathological joints

Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes.

Article specifications

This research study was published in 2019 in Journal of Biomed Res Int. (IF 2017: 2.583) by Italian specialists. The aim of this study was to investigate the anti-inflammatory effects and properties of hybrid cooperative complexes based on high and low molecular weight hyaluronan (HCC) compared to H-HA on human primary cells derived by pathological joints.

 

Results

The results of the rheological characterization indicate that HCC may provide suitable viscosupplementation combined with proper injectability. HCC had an anti-inflammatory effect on human chondrocytes and synoviocytes when isolated from pathological knee joints. The results of all experiments performed showed that HCC were more effective than linear H-HA. HCC reduced IL-6 and IL-8 gene expression levels as well as COMP-2 and NF-kB protein expression in both cells types populating human joints. Also, HCC gels prompted synoviocytes proliferation. Future in vivo models will better validate HCC as a therapeutic tool for the management of OA.