Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid

Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid: An in Vivo Canine Model

Article specifications

This review study was published in 2006 in journal of J Bone Joint Surg Am. (IF: 2016:4.840) by American specialists. The purpose of this study was to test the hypothesis that surface modification of an extrasynovial tendon with use of a carbodiimide-derivatized hyaluronic acidgelatin polymer (cd-HA) improves gliding ability and digital function after tendon grafting in a canine model in vivo. The peroneus longus tendons from both hindpaws of twenty-four dogs were harvested and transplanted to replace the flexor digitorum profundus tendons in the second and fifth digits of one forepaw. Prior to grafting, one of the peroneus longus tendons was coated with cd-HA, which consists of 1% hyaluronic acid, 10% gelatin, 0.25% 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), and 0.25% N-hydroxysuccinimide (NHS), while the other was immersed in saline solution only. Eight dogs were killed at one, three, and six weeks.

 

Result

Treating the surface of an extrasynovial tendon autograft with a carbodiimidederivatized hyaluronic acid-gelatin polymer decreases digital work of flexion and tendon gliding resistance in this flexor tendon graft model in vivo.