Flexor tendon injuries and Hyaluronic acid

EFFECTS OF HYALURONIC ACID SIZE ON ADHESIONS IN FLEXOR TENDON INJURIES

Article specifications

This clinical study was published in 2017 in Journal of Orthopaedic Research (IF 2017:3.14) by Japanese orthopedics. The purpose of this investigation was to test the hypothesis that the effect of HA may depend on surrounding condition where the repaired tendon is placed during its healing. One hundred and twenty 3-month-old male white Leghorn chickens were used for experimental animals.

 

Result

High molecular weight HA (202X104) was more effective than low molecular weight HA (95X104, 46X104) in the prevention of restrictive adhesions after tenorrhaphy when the sutured tendon was kept in the subcutaneous tissue outside the tendon sheath. This result suggests that high molecular weight HA application would be useful for expecting less adhesion and faster recovery of gliding function of the tendon if the inflammatory reaction and swelling are minimal during postoperative phase.