How CS and HA affect the tendon tissue and fibroblasts in vitro and in rats

Effects of Corticosteroids and Hyaluronic Acid on Torn Rotator Cuff Tendons In Vitro and in Rats

Article specifications

This clinical trial was published in 2015 in Journal of J Orthop Res. (IF 2017:3.14) by Japanese specialists. This study aimed to address the question of how CS and HA affect the tendon tissue and fibroblasts in vitro and in rats

 

Results

In conclusion, we demonstrated in vitro and in rats that unlike HA, CS caused cell death and inhibited the proliferation of tendon fibroblasts, leading to a delay of tendon healing and a subsequent decrease of biomechanical strength in the rat model; however, these changes improved 4 weeks after surgery. Therefore, clinicians should recognize the different characteristics of these agents when treating RCT.