A review on the use of hyaluronic acid in tympanic membrane wound healing
This review article was published in 2012 in journal of Expert Opin Biol Ther (IF: 2.33) by Australian Otolaryngologists.
In this study the researchers conducted a search with Pub med (1976 -- 2011) using search terms (and combination of terms) that included but were not limited to ‘hyaluronic acid’, ‘tympanic membrane’, ‘tympanic membrane perforation’, ‘wound healing’, ‘safety’ and ‘efficacy’. Articles were also hand searched. A total of 10 animal and 12 human trials evaluating the efficacy of hyaluronic acid and its derivatives in tympanic membrane wound healing were identified.
The results of 10 animal study showed that the treatment with hyaluronic acid shortens the tympanic membrane healing period compared with controls. And in 12 clinical trial showed that Perforations caused by trauma were healed in all cases with a quicker response. Perforations due to acute otitis media completely healed in 60% of cases compared with only 25% in chronic otitis media. The studies also showed that hyaluronic acid is biodegradable in ear and is safe and efficient treatment tympanic membrane wound healing