Improvement in subacute and chronic otitis media with effusion through the administration of Hyaluronic acid

Clinical Improvement of Subacute and Chronic Otitis Media With Effusion Treated With Hyaluronic Acid Plus Hypertonic Solution via Nasal Lavage: A Randomized Controlled Trial

Article specifications

This clinical trial was published in 2017 in Journal of Glob Pediatr Health. (IF 2015:1.43) by Italian specialists. This study aims to demonstrate a clinically significant improvement in subacute and chronic otitis media with effusion through the administration of hyaluronic acid associated with hypertonic solution compared with the administration of hypertonic solution alone. The study was conducted for 6 months, from October 2014 to the end of March 2015. The study saw the participation of 20 pediatricians who were experts in pneumatic otoscopy, each of whom enrolled 15 children. A total of 264 children completed the trial according to the protocol, 120 in the hyaluronic acid + hypertonic solution group and 144 in the hypertonic solution group.

 

Results

The association of hyaluronic acid with hypertonic solution has proven to be significantly more effective than hypertonic solution alone, which is effective per se as we have proven in our study. The significant savings in drugs is quite interesting and can open the way to new scenarios in the therapy of OME. Clearly, larger and particularly double-blind studies need to be conducted to confirm this hypothesis. However, at present hyaluronic acid has proven to be safe and effective in the treatment of OME.