Hyaluronic acid ester in myringoplasty

Hyaluronic acid ester in myringoplasty

Article specifications

This clinical study was published in 2007 in The Journal of Laryngology & Otology (IF2015: 0.44) by British Otolaryngologists. In this study the safety and effectiveness of use of esterified hyaluronic acid in tympanic membrane perforations in patients who hitherto had been denied surgical myringoplasty. This study included 20 patients, all had a persistent, symptomatic tympanic membrane perforation in at least one ear. Under general anesthesia, the edges of the perforation were freshened and a sheet of Epifilm (esterified hyaluronic acid), trimmed to a size roughly 2 mm larger in diameter than the perforation, was tucked through the perforation. Patients were seen two weeks post-operatively in the out-patients department and reassessed.

Results

Results of the study showed that repair of tympanic membrane perforations with hyaluronic acid ester films is not to be recommended.