Implantation of Esterified Hyaluronic Acid in Microdissected Reinke’s Space after Vocal Fold Microsurgery: Short-and Long-Term Results

Implantation of Esterified Hyaluronic Acid in Microdissected Reinke’s Space after Vocal Fold Microsurgery: Short-and Long-Term Results. A prospective, comparative, not randomized, clinical study

Article specifications

This clinical study was published in 2008 in Journal of Voice (IF2015: 1.19) in Belgium.  The aim of the study is to evaluate the safety and efficacy of esterified hyaluronic acid (EHA). This study included 83 subjects are included in the study and undergo a microsurgical treatment of benign VF lesions. Thirty-three cases benefit from immediate implantation of a resorbable bio implant made of EHA in the surgical wound. Fifty cases do not undergo implantation at the end of the microsurgical procedure.

 

Results

The results of the study showed that early postoperative results are similar in both groups: a significant improvement of a majority of laryngeal and vocal data is observed after microsurgery. In the long term, the two groups exhibit a different behavior: further improvement of voice, as an ongoing process, is only observed in the EHA (esterified hyaluronic acid) implanted group, together with improvement of some videostroboscopic characteristics. The nonimplanted group remains stable, with no further improvement of the voice quality obtained after microsurgery. Excellent short- and long-term tolerance of EHA implantation is confirmed by this larger series. The use of EHA implant in micro dissected SLLP is safe and leads to good laryngeal and vocal outcomes in the treated patients. More interestingly, treated cases exhibit a continuous improvement over a long period of time.